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How Weider Muscle Health Works



Weider Muscle Health is a between-meals, targeted nutritional supplement designed to minimize muscle protein degradation that occurs when liver glycogen is depleted as nutrient influx from the previous meal is exhausted. While generally not a problem in young people, as we age, the disparity between calories “in” and calories “out” becomes greater, and as a result, muscle tissue is called upon much more frequently to supply energy and nutrients to support whole-body metabolism. This is particularly a problem in men and women of advancing years. This disparity between calorie intake and expenditure is slow and insidious.

Increasingly, the muscle loss (strength and mass) that once was believed to be a natural/normal aspect of aging is now considered to be a conflation of many untoward processes, all of which may contribute to loss of muscle mass and strength as we age.

Normal metabolism is a homeostatic balance of catabolic and anabolic processes; however, as we age there is an almost implacable imbalance toward catabolism...an imbalance that slowly decreases muscle mass and strength year after year. The amount of muscle mass an individual carries is now associated with quality of life, long-term survival, and cognition. As muscle mass and strength decline, so does our ability to withstand illness and trauma.

One characteristic of muscle loss due to aging is an increase in body fat. This occurs for several reasons, one of which is because muscle protein is used more often for energy in aging individuals than body fat. Protecting muscle protein between meals forces the body to increase fat metabolism, helping to maintain lean muscle mass while decreasing fat stores.3 Many of the processes implicated in age-related muscle loss are complex and ill-defined and therefore difficult to control or avoid.4 However, two contributing factors more easily controlled and modified are: 1) the amount and timing of stabilizing energy nutrients (including daily protein intake), and 2) regular exercise, including both aerobic and resistance exercise.

One critical nutritional strategy is to use specialized nutrients to bridge the time the body exhausts nutrient influx from the previous meal to the next meal. The nutrients in Weider Muscle Health support an increase in skeletal muscle energy charge, which mitigates catabolic muscle metabolism that may occur in aging individuals between meals, particularly individuals with large disparities between calorie intake and expenditure.

Weider Muscle Health’s targeted formula contains B-vitamins, Vitamin D, Leucine, Arginine, Medium Chain Triglycerides, and a 95% proanthocyanidins pine bark extract. These nutrients work in concert to provide short chain fatty acids and ketoacids that quickly stabilize muscle energy charge, mitigating catabolic muscle metabolism.

Leucine is a special amino acid that increases energy charge and skeletal muscle protein synthesis. Leucine supplementation is one of the quickest ways to stabilize the energy charge of skeletal muscle when glucose levels are insufficient.5 Vitamin D deficiency is a risk factor for muscle myopathy; therefore, resolving deficiency is important for muscle health and well-being.*6 Arginine and proanthocyanidins work in concert, supporting vascular health and healthy blood flow.7 MCTs (medium chained triglycerides) are converted in the liver to hydroxybutyrate and acetoacetate, which provide muscle extra energy. These two products of fat metabolism increase energy charge while decreasing oxygen consumption due to their unique effects on TCA redox coupling. Serum glucogenic amino acids are spared and fat metabolism is increased as muscle energy charge is stabilized.

Weider Muscle Health helps protect muscle protein from catabolic metabolism between meals by supplying critical energy components that help stabilize muscle metabolism during the periods between meals when muscle typically supplies glucogenic amino acids to support energy metabolism. Since serum glucogenic amino acids are spared, fat metabolism is increased to off-set energy deficits. For best results, Weider Muscle Health should be taken between meals and used in conjunction with a protein intake of about 30 grams of protein per main meal (0.5-0.75 g/lb bodyweight/day) as well as exercising 30 to 40 minutes, 3-4 times per week.

*Although two servings of Weider Muscle Health contain 100% of the recommended daily intake for Vitamin D, Weider Muscle Health is not an appropriate supplement to treat acute Vitamin D deficiency.

Allen DL, Cleary AS, Lindsay SF, Loh AS, Reed JM (2010). Myostatin expression is increased by food deprivation in a muscle-specific manner and contributes to muscle atrophy during prolonged food deprivation in mice. J Appl Physiolog, 109(3):692-701. Bach AC, Ingenbleek Y, Frey A (1996). The usefulness of dietary medium-chain triglycerides in body weight control: fact or fancy? Journal of Lipid Research, 37(4):708-26. Beaufrere B, Tessari P, Cattalini M, Miles J, Haymond MW (1985). Apparent decreased oxidation and turnover of leucine during infusion of medium-chain triglycerides. Am J Physiology, 249(2 Pt 1):E175-82. Cahill GF Jr. (2006). Fuel metabolism in starvation. Annu Rev Nutr,26:1-22. Cooke JP (2010). DDAH: a target for vascular therapy? Vasc Med, 15(3):235-8. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People (2010). Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing, 39(4):412-23. Dardevet D, Rieu I, Fafournoux P, Sornet C, Combaret L, Bruhat A, Mordier S, Mosoni L, Grizard J (2003). Leucine: a key amino acid in ageing-associated sarcopenia? Nutrition Research Reviews, 16(1):61-70. Doherty TJ (2003). Invited review: Aging and sarcopenia. J Appl Physiology, 95(4):1717-27. Drummond MJ, McCarthy JJ, Sinha M, Spratt HM, Volpi E, Esser KA, Rasmussen BB (2011). Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis. Phisiol Genomics, 43(10):595-603. Flatt JP, Blackburn GL (1974). The metabolic fuel regulatory system: implications for protein-sparing therapies during caloric deprivation and disease. The American Journal of Clinical Nutrition, 27(2):175-87. Forstermann U (2010). Nitric oxide and oxidation in vascular disease. Eur J Physiology, 459: 923-939. Fujita S, Volpi E (2006). Amino acids and muscle loss with aging. The Journal of Nutrition, 136(1 Suppl):277S-80S. Hays NP, Roberts SB (2006). The anorexia of aging in humans. Physiology & Behavior, 88(3):257-66. Heaney RP (2004). Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr, 80:1706S-9S. Katsanos CS, Chinkes DL, Paddon-Jones D, Zhang XJ, Aarsland A, Wolfe RR (2008). Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutr Res, 28(10):651-8. Koopman R, van Loon LJ (2009). Aging, exercise, and muscle protein metabolism. J Appl Physiology, 106(6):2040-8. Koopman R (2010). Conference on ‘Nutrition and health: cell to community’ Symposium 2: Exercise and protein nutrition Dietary protein and exercise training in ageing. Proceedings of the Nutrition Society, 70(1):104-13. Löw P (2011). The role of ubiquitin-proteasome system in ageing. General and Comparative Endocrinology. 172(1):39-43. McCarthy JJ, Esser KA (2010). Anabolic and catabolic pathways regulating skeletal muscle mass. Curr Opin Clin Nutr Metab Care, 13(3):230-5. Metter EJ, Talbot LA, Schrager M, Conwit R (2002). Skeletal muscle strength as a predictor of all-cause mortality in healthy men. Journal of Gerontology: Biological Science, 57(10):B359-65. Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NE, Doehner W, FearonKC, Ferrucci L, Hellerstein MK, Kalantar-Zadeh K, Lochs H, MacDonald N, Mulligan K, Muscaritoli M, Ponikowski P, Posthauer ME, Rossi Fanelli F, Schambelan M,Schols AM, Schuster MW, Anker SD (2010), Disease. Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc. 11(6):391-6. Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NE, Doehner W, Fearon KC, Ferrucci L, Hellerstein MK, Kalantar-Zadeh K, Lochs H, MacDonald N, Mulligan K, Muscaritoli M, Ponikowski P, Posthauer ME, Rossi Fanelli F, Schambelan M, Schols AM, Schuster MW, Anker SD; Society for Sarcopenia, Cachexia, and Wasting Disease (2010). Nutritional recommendations for the management of sarcopenia. J American Directors Association, 11(6):391-6. Muscaritoli M, Anker SD, Argilés J, Aversa Z, Bauer JM, Biolo G, Boirie Y, Bosaeus I, Cederholm T, Costelli P, Fearon KC, Laviano A, Maggio M, Rossi Fanelli F, Schneider SM, Schols A, Sieber CC (2010). Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clinical Nutrition, 29(2):154-9. Paddon-Jones D, Rasmussen BB (2009). Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care, 12(1):86-90. Paddon-Jones D (2006). Interplay of stress and physical inactivity on muscle loss: Nutritional countermeasures. The Journal of Nutrition, 136(8):2123-6. Patil CK, Mian IS, Campisi J (2005). The thorny path linking cellular senescence to organismal aging. Mechanisms of Ageing and Development, 126(10):1040-5. Rolland Y, Dupuy C, Abellan van Kan G, Gillette S, Vellas B (2011). Treatment strategies for sarcopenia and frailty. Med Clin N Am, 95(3):427-38. Sapir DG, Owen OE, Pozefsky T, Walser M (1974). Nitrogen sparing induced by a mixture of essential amino acids given chiefly as their keto-analogues during prolonged starvation in obese subjects. The Journal of Clinical Investigation, 54(4):974-80. Sherwin RS, Hendler RG, Felig P(1975). Effect of ketone infusions on amino acid and nitrogen metabolism in man. The Journal of Clinical Investigation, 55(6):1382-90. Sherwin RS (1978). Effect of starvation on the turnover and metabolic response to leucine. Journal of Clinical Investigation, 61(6):1471-81. Sugawara T, Ito Y, Nishizawa N, Nagasawa T (2009). Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet. Amino Acids, 37(4):609-16. Timmerman KL, Volpi E (2008). Amino acid metabolism and regulatory effects in aging. Curr Opin Clin Nutr Metab Care, 11(1):45-9. von Haehling S, Morley JE, Anker SD (2010). An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachex Sarcopenia Muscle, 1(2):129-133. Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF Jr (2001). Ketone bodies, potential therapeutic uses. IUBMB Life, 51(4):241-7. Veech RL (2004). The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukotrienes Essential Fatty Acid, 70(3):309-19. Wolfe RR (2006). Skeletal muscle protein metabolism and resistance exercise. The Journal of Nutrition, 136(2):525S-528S. Wolfe RR (2006). The underappreciated role of muscle in health and disease. The American Journal of Clinical Nutrition, 84(3):475-82. Zold E, Barta Z, Bodolay E (2011). Vitamin D deficiency and connective tissue disease. Vitam Horm, 86: 261-86.





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